Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy.
Identifieur interne : 002182 ( Main/Exploration ); précédent : 002181; suivant : 002183Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy.
Auteurs : Gaku Yamanaka [Japon] ; Hisashi Kawashima ; Yusuke Suganami ; Chiako Watanabe ; Yoshiaki Watanabe ; Tasuku Miyajima ; Kouji Takekuma ; Satoshi Oguchi ; Akinori HoshikaSource :
- Journal of the neurological sciences [ 0022-510X ] ; 2006.
Descripteurs français
- KwdFr :
- Diagnostic différentiel, Encéphalite virale (), Encéphalite virale (diagnostic), Encéphalite virale (sang), Enfant, Enfant d'âge préscolaire, Espèces réactives de l'oxygène (), Espèces réactives de l'oxygène (sang), Femelle, Grippe humaine (), Humains, Interleukine-6 (sang), Marqueurs biologiques (), Marqueurs biologiques (sang), Mâle, Numération des leucocytes, Numération des plaquettes, Orthomyxoviridae (immunologie), Radicaux libres (), Radicaux libres (sang), Stress oxydatif (physiologie), Valeur prédictive des tests.
- MESH :
- diagnostic : Encéphalite virale.
- immunologie : Orthomyxoviridae.
- physiologie : Stress oxydatif.
- sang : Encéphalite virale, Espèces réactives de l'oxygène, Interleukine-6, Marqueurs biologiques, Radicaux libres.
- Diagnostic différentiel, Encéphalite virale, Enfant, Enfant d'âge préscolaire, Espèces réactives de l'oxygène, Femelle, Grippe humaine, Humains, Marqueurs biologiques, Mâle, Numération des leucocytes, Numération des plaquettes, Radicaux libres, Valeur prédictive des tests.
English descriptors
- KwdEn :
- Biomarkers (blood), Biomarkers (cerebrospinal fluid), Child, Child, Preschool, Diagnosis, Differential, Encephalitis, Viral (blood), Encephalitis, Viral (cerebrospinal fluid), Encephalitis, Viral (diagnosis), Female, Free Radicals (blood), Free Radicals (cerebrospinal fluid), Humans, Influenza, Human (complications), Interleukin-6 (blood), Leukocyte Count, Male, Orthomyxoviridae (immunology), Oxidative Stress (physiology), Platelet Count, Predictive Value of Tests, Reactive Oxygen Species (blood), Reactive Oxygen Species (cerebrospinal fluid).
- MESH :
- chemical , blood : Biomarkers, Free Radicals, Interleukin-6, Reactive Oxygen Species.
- chemical , cerebrospinal fluid : Biomarkers, Free Radicals, Reactive Oxygen Species.
- blood : Encephalitis, Viral.
- cerebrospinal fluid : Encephalitis, Viral.
- complications : Influenza, Human.
- diagnosis : Encephalitis, Viral.
- immunology : Orthomyxoviridae.
- physiology : Oxidative Stress.
- Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Leukocyte Count, Male, Platelet Count, Predictive Value of Tests.
Abstract
The aim of this study was to assess the validity of serum and CSF oxidative status of patients with IE in their initial stage through the d-ROM (Diacron-Reactive Oxygen Metabolites, Italy) test, compared to those with other neurological diseases. The study was conducted on the following four groups: (1) influenza virus-associated encephalopathy (IE, n = 8), including four patients showing neurological sequelae or mortal; (2) influenza virus-associated febrile seizures (IFS, n = 11); (3) febrile convulsion (FC, n = 10): (4) enterovirus-associated encephalopathy (EE, n = 4), including one patient with neurological sequelae. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and the FC groups but not in the EE group. In addition, general laboratory findings such as leukocytes, platelets, C-reactive protein, aspartate aminotransferase, creatinine, creatinine kinase and LDH, including interleukin-6 (IL-6), were analyzed in each group. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and FC groups but not in the EE group. As for the serum d-ROM levels and general laboratory findings, with the exception of CSF IL-6 levels in IE, no significant differences were detected compared with the other groups. In patients with IE, the CSF d-ROM levels could be a valid predictive biomarker of the severity, and oxidative stress may be related to the pathogenesis of IE.
DOI: 10.1016/j.jns.2005.11.029
PubMed: 16413581
Affiliations:
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last="Suganami">Yusuke Suganami</name></author><author><name sortKey="Watanabe, Chiako" sort="Watanabe, Chiako" uniqKey="Watanabe C" first="Chiako" last="Watanabe">Chiako Watanabe</name></author><author><name sortKey="Watanabe, Yoshiaki" sort="Watanabe, Yoshiaki" uniqKey="Watanabe Y" first="Yoshiaki" last="Watanabe">Yoshiaki Watanabe</name></author><author><name sortKey="Miyajima, Tasuku" sort="Miyajima, Tasuku" uniqKey="Miyajima T" first="Tasuku" last="Miyajima">Tasuku Miyajima</name></author><author><name sortKey="Takekuma, Kouji" sort="Takekuma, Kouji" uniqKey="Takekuma K" first="Kouji" last="Takekuma">Kouji Takekuma</name></author><author><name sortKey="Oguchi, Satoshi" sort="Oguchi, Satoshi" uniqKey="Oguchi S" first="Satoshi" last="Oguchi">Satoshi Oguchi</name></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name></author></titleStmt><publicationStmt><idno 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Yusuke" uniqKey="Suganami Y" first="Yusuke" last="Suganami">Yusuke Suganami</name></author><author><name sortKey="Watanabe, Chiako" sort="Watanabe, Chiako" uniqKey="Watanabe C" first="Chiako" last="Watanabe">Chiako Watanabe</name></author><author><name sortKey="Watanabe, Yoshiaki" sort="Watanabe, Yoshiaki" uniqKey="Watanabe Y" first="Yoshiaki" last="Watanabe">Yoshiaki Watanabe</name></author><author><name sortKey="Miyajima, Tasuku" sort="Miyajima, Tasuku" uniqKey="Miyajima T" first="Tasuku" last="Miyajima">Tasuku Miyajima</name></author><author><name sortKey="Takekuma, Kouji" sort="Takekuma, Kouji" uniqKey="Takekuma K" first="Kouji" last="Takekuma">Kouji Takekuma</name></author><author><name sortKey="Oguchi, Satoshi" sort="Oguchi, Satoshi" uniqKey="Oguchi S" first="Satoshi" last="Oguchi">Satoshi Oguchi</name></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="ISSN">0022-510X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (blood)</term><term>Biomarkers (cerebrospinal fluid)</term><term>Child</term><term>Child, Preschool</term><term>Diagnosis, Differential</term><term>Encephalitis, Viral (blood)</term><term>Encephalitis, Viral (cerebrospinal fluid)</term><term>Encephalitis, Viral (diagnosis)</term><term>Female</term><term>Free Radicals (blood)</term><term>Free Radicals (cerebrospinal fluid)</term><term>Humans</term><term>Influenza, Human (complications)</term><term>Interleukin-6 (blood)</term><term>Leukocyte Count</term><term>Male</term><term>Orthomyxoviridae (immunology)</term><term>Oxidative Stress (physiology)</term><term>Platelet Count</term><term>Predictive Value of Tests</term><term>Reactive Oxygen Species (blood)</term><term>Reactive Oxygen Species (cerebrospinal fluid)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Diagnostic différentiel</term><term>Encéphalite virale ()</term><term>Encéphalite virale (diagnostic)</term><term>Encéphalite virale (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Espèces réactives de l'oxygène ()</term><term>Espèces réactives de l'oxygène (sang)</term><term>Femelle</term><term>Grippe humaine ()</term><term>Humains</term><term>Interleukine-6 (sang)</term><term>Marqueurs biologiques ()</term><term>Marqueurs biologiques (sang)</term><term>Mâle</term><term>Numération des leucocytes</term><term>Numération des plaquettes</term><term>Orthomyxoviridae (immunologie)</term><term>Radicaux libres ()</term><term>Radicaux libres (sang)</term><term>Stress oxydatif (physiologie)</term><term>Valeur prédictive des tests</term></keywords><keywords scheme="MESH" type="chemical" 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qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Encéphalite virale</term><term>Espèces réactives de l'oxygène</term><term>Interleukine-6</term><term>Marqueurs biologiques</term><term>Radicaux libres</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Leukocyte Count</term><term>Male</term><term>Platelet Count</term><term>Predictive Value of Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Diagnostic différentiel</term><term>Encéphalite virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Espèces réactives de l'oxygène</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Numération des leucocytes</term><term>Numération des plaquettes</term><term>Radicaux libres</term><term>Valeur prédictive des tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to assess the validity of serum and CSF oxidative status of patients with IE in their initial stage through the d-ROM (Diacron-Reactive Oxygen Metabolites, Italy) test, compared to those with other neurological diseases. The study was conducted on the following four groups: (1) influenza virus-associated encephalopathy (IE, n = 8), including four patients showing neurological sequelae or mortal; (2) influenza virus-associated febrile seizures (IFS, n = 11); (3) febrile convulsion (FC, n = 10): (4) enterovirus-associated encephalopathy (EE, n = 4), including one patient with neurological sequelae. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and the FC groups but not in the EE group. In addition, general laboratory findings such as leukocytes, platelets, C-reactive protein, aspartate aminotransferase, creatinine, creatinine kinase and LDH, including interleukin-6 (IL-6), were analyzed in each group. The CSF d-ROM levels in the IE group were significantly higher than those in the IFS and FC groups but not in the EE group. As for the serum d-ROM levels and general laboratory findings, with the exception of CSF IL-6 levels in IE, no significant differences were detected compared with the other groups. In patients with IE, the CSF d-ROM levels could be a valid predictive biomarker of the severity, and oxidative stress may be related to the pathogenesis of IE.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name><name sortKey="Miyajima, Tasuku" sort="Miyajima, Tasuku" uniqKey="Miyajima T" first="Tasuku" last="Miyajima">Tasuku Miyajima</name><name sortKey="Oguchi, Satoshi" sort="Oguchi, Satoshi" uniqKey="Oguchi S" first="Satoshi" last="Oguchi">Satoshi Oguchi</name><name sortKey="Suganami, Yusuke" sort="Suganami, Yusuke" uniqKey="Suganami Y" first="Yusuke" last="Suganami">Yusuke Suganami</name><name sortKey="Takekuma, Kouji" sort="Takekuma, Kouji" uniqKey="Takekuma K" first="Kouji" last="Takekuma">Kouji Takekuma</name><name sortKey="Watanabe, Chiako" sort="Watanabe, Chiako" uniqKey="Watanabe C" first="Chiako" last="Watanabe">Chiako Watanabe</name><name sortKey="Watanabe, Yoshiaki" sort="Watanabe, Yoshiaki" uniqKey="Watanabe Y" first="Yoshiaki" last="Watanabe">Yoshiaki Watanabe</name></noCountry><country name="Japon"><noRegion><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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